alpha-(Trifluoromethyl)benzyl alcohol

alpha-(Trifluoromethyl)benzyl alcohol - Names and Identifiers

Name	1-Phenyl-2,2,2-trifluoroethanol
Synonyms	1-Phenyl-2,2,2-trifluoroethanol ALPHA-(TRIFLUOROMETHYL)BENZYL A (±)-Phenyl-2,2,2-trifluoroethanol alpha-(Trifluoromethyl)benzyl alcohol beta,beta,beta-Trifluoro-alpha-hydroxyethylbenzene 1-Phenyl-2,2,2-trifluoroethanol,a-Trifluoromethylbenzyl alcohol
CAS	340-05-6
EINECS	206-429-1
InChI	InChI=1/C8H7F3O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5,7,12H

alpha-(Trifluoromethyl)benzyl alcohol - Physico-chemical Properties

Molecular Formula	C8H7F3O
Molar Mass	176.14
Density	1.297g/mLat 20°C(lit.)
Melting Point	74.3-75.2 °C
Boling Point	64-65°C5mm Hg(lit.)
Flash Point	184°F
Appearance	liquid
Specific Gravity	1.293
Color	Colorless to Brown
BRN	3197623
pKa	11.91±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	n20/D 1.462
MDL	MFCD00004498

alpha-(Trifluoromethyl)benzyl alcohol - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
FLUKA BRAND F CODES	10-23
HS Code	29062990
Hazard Class	IRRITANT

alpha-(Trifluoromethyl)benzyl alcohol - Introduction

1-Phenyl-2,2,2-trifluoroethanol is an organic compound with the chemical formula C8H7F3O. It is a colorless liquid with a pungent, aromatic smell.

As a reaction reagent, 1-Phenyl-2,2,2-trifluoroethanol has a wide range of uses in organic synthesis. It can be used to catalyze substitution reactions of alcohols, such as addition reactions of olefins. In addition, it is a strongly acidic reagent that can be used in acid-catalyzed reactions, such as esterification reactions and acid-catalyzed carbon-carbon bond formation reactions.

There are many ways to prepare 1-Phenyl-2,2,2-trifluoroethanol. One common method is by reacting fluoroethanol with phenyl bromide. It is first necessary to prepare sodium p-trifluorotoluene sulfonate (para-Trifluoromethanesulfonic acid sodium salt), and then react it with fluoroethanol under acidic conditions to obtain 1-Phenyl-2,2,2-trifluoroethanol.

Regarding safety information, 1-Phenyl-2,2,2-trifluoroethanol is an organic substance, and safety measures should be paid attention to when using it. It is a combustible substance and needs to be kept away from fire and high temperatures. In the process of use, should avoid contact with oxidants, strong bases and strong acids to prevent the occurrence of dangerous reactions. It is also recommended to wear suitable protective equipment, such as gloves and eye protection, to ensure safe use.

Last Update：2024-04-10 22:29:15